Computer aided process engineering (CAPE) tools have been very successfully used in process design and product engineering for a long time. In particular, simulation and modelling tools have enabled engineers to analyse and understand the behaviour of selected processes prior to building actual plants. CAPE tools are also widely applied to monitor and optimize the operating conditions of existing plants, thus minimizing raw materials and energy usage, and reducing wastes and emissions. The aim of design or retrofit of chemical processes is to produce profitably products that satisfy the societal needs, ensuring safe and reliable operation of each process, as well as minimising any effects on the environment. This involves the conceptual design or retrofit of plants and processes, the investigation of novel manufacturing approaches. Interactions between the process and the control system operability, manufacturability, environment protection and safety are key issues that can only be addressed by proper integration of several tools.